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Osteoporosis & Bone Health | Last Active: 2 hours ago | Replies (74)
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@wilweten but I question the data and how humans respond to the maximum dose of 80 mcg. When I looked at results from clinical trials it gave data on many conditions that participants experienced, none of it actually an outcome of the medication apparently, but I don't recall seeing meaningful data on bone cancer. As for the rats, even at lower doses, a certain percentage of them developed bone cancer, just a lower percentage.
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@willowmena This article "The Risk of Developing Osteosarcoma After Teriparatide Use: A Systematic Review" might be of interest to you: https://pmc.ncbi.nlm.nih.gov/articles/PMC10544053/
Yes, it's not about abaloparatide, but about teriparatide, which has a lot in common with abaloparatide. And yes, the situation may not crystal clear, but it looks rather positive. However, if my situation wasn't so severe, I wouldn't dream of taking the risks of osteoporosis medicine...
It says e.g.: "clinical trials and post-marketing surveillance studies did not demonstrate any increased risk of osteosarcoma, even after prolonged periods of surveillance reaching up to 15 years, with most of the identified cases of osteosarcomas being solitary and predominantly attributed to other factors. This systematic review provides a comprehensive overview of the currently available literature and provides the highest level of clinical evidence towards demonstrating the lack of any substantial evidence towards osteosarcoma development in patients utilizing TPTD."