Connect
← Return to Anyone actually feel better on any of these drugs?
Discussion
Anyone actually feel better on any of these drugs?
Osteoporosis & Bone Health | Last Active: Sep 8 12:43am | Replies (43)Comment receiving replies
OP drugs remodel bone architecture. You will not "feel better" (more rested, stronger, etc)
by just taking them.
I am taking Tymlos and I "feel better" because after 13 months I found via a DEXA scan that my spine bmd increased by 10.4%. I also "feel better" knowing that with Tymlos I have a
1. 86% relative reduction in new spine fractures.
2. 43% relative reduction in nonvertebral fractures (such as wrists, ribs, and other skeletal sites, excluding things like fingers, toes, and the skull).
See https://www.drugs.com/medical-answers/how-tymlos-increase-bone-density-3581147/
I am a small 100lb female, and, fortunately, have had no side effects on Tymlos.
Replies to "OP drugs remodel bone architecture. You will not "feel better" (more rested, stronger, etc) by just..."
@roseincalifornia Did you know any bone loss in wrists while on this drug? I am also small framed female with very thin wrists. Dr. McCormick mentioned in his book that he saw bone loss in wrists in a few of his patients on Tymlos, just wondering if you noticed any bone loss there. Thank you in advance.
@roseincalifornia What about your hips? Any improvement in score?
Connect
@roseincalifornia
I have a problem when I see "relative risk reduction" versus "actual risk reduction". Relative risk reduction seems to be the preferred metric used by pharma. From Google:
Relative Risk Reduction (RRR) measures the percentage drop in risk between an experimental group and a control group. Actual or Absolute Risk Reduction (ARR) measures the true mathematical difference in risk between the two groups. RRR often sounds massive and exaggerates a treatment's effect, while ARR shows the actual real-world benefit.
Clear Comparison Example: Imagine a clinical study for a new heart pill tested on 10,000 people over a year. Control Group (no pill): 200 out of 5,000 people (4%) have a heart attack. Treated Group (with pill): 100 out of 5,000 people (2%) have a heart attack.
The RRR is 50% because the risk dropped from 4% down to 2%—a half-size reduction in the rate itself.
The ARR is 2% because the actual percentage difference is 4% - 2%. Out of 100 people who take the pill, only 2 people are actively saved from a heart attack.
Marketing and Media: News headlines love using RRR (e.g., "Cuts risk in half!") because it sounds impressive, even if the actual risk was tiny to begin with.