@marko49 I am a big proponent of focal therapy. Looked at IRE, Laser, and Tulsa Pro. Was not a good candidate for any of these a couple of years ago. What I noticed in the study was that most of the inappropriate use was for Gleason 6. Percentage of Gleason 8 & 9 with focal therapy had large decreases. If someone with a 6 cannot take the thought of active surveillance any focal therapy is better than RT or RP. It is bad enough that most insurance will not cover these treatments.