← Return to Half of Prostate Cancer Focal Therapy Cases Were Inappropriate

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I'm unsure if my IRE nanoknife focal therapy was inappropriate? Perhaps yes and perhaps no. After much reading and being afraid of both surgery and radiation, I sought out a place that might offer focal therapy. At a Philadelphia center of excellence I was told that I was a good candidate. Having 4+3=7 gleason with tumor being only one side of the gland and after several tests including PSMA PET scan which showed no metastasis they told me I was a good candidate. The procedure went well and was confirmed effective by both imaging and biopsy 7 months later. Unfortunately, another 6 months later due to a rise in PSA another PSMA PET was performed indicating metastasis in pelvic lymph nodes. Doctor opined micro metastasis that was not picked up in earlier PSMA PET. I was definitively disappointed but I don't regret taking a chance at it. After which there wasn't too much of a decision process. ADT + ARPI + 40 sessions of IMRT which so far has been effective with PSA being <.05 consistently over a year. Anyhow do you think in my case this was an inappropriate decision by me and my Urological Oncologist?

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Replies to "I'm unsure if my IRE nanoknife focal therapy was inappropriate? Perhaps yes and perhaps no. After..."

@swl1956 It is unlikely that the metastasis occurred and grew large enough to show on a PSMA in 6 months. With RP they do not take all lymph nodes so you could be in the same situation if you chose surgery. Even with RT, depending on how far the nodes are from the prostate they could have been outside the zone of treatment. ROs try to minimize that to reduce side effects. Now if they had lit up on the previous PSMA than the RT treatment would have included them.