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Profile picture for Jeff Marchi @jeffmarc

Well, this seems to be less than brand new technology. It also isn’t being used in many places yet, it seems to be a step up in capability.

Mayo Clinic installs 1st Quadra PET/CT scanner in North America
https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-installs-1st-quadra-pet-ct-scanner-in-north-america/
Then there are Immunotherapy Solutions for prostate cancer VIR-5500 and others
https://www.theguardian.com/society/2026/feb/28/researchers-praise-stunning-results-of-new-prostate-cancer-treatment
https://www.sciencealert.com/new-experimental-drug-shrinks-tumors-in-prostate-cancer-clinical-trial
https://online.flippingbook.com/link/677451/10/
There is one group trying to find a way to detect dormant prostate cancer cells, That would be a big step in preventing BCR.

There are a lot of other clinical trials I have read about

The study focused on men with metastatic castration-resistant prostate cancer – an aggressive form of the disease that has spread and no longer responds to hormone-blocking treatments.
https://www.news-medical.net/news/20260515/Multi-institutional-trial-explores-new-lifeline-for-advanced-prostate-patients.aspx
Developing effective therapies for prostate cancer bone metastasis—a final stage of prostate cancer progression without any effective treatments—is a medical priority,”
https://www.masseycancercenter.org/news/2026/innovative-targeted-therapy-halts-prostate-cancer-spread-to-the-bone/
promising antitumor activity with combination of pasritamig and docetaxel in advanced prostate cancer
https://www.jnj.com/media-center/press-releases/early-study-results-from-johnson-johnson-show-promising-antitumor-activity-with-combination-of-pasritamig-and-docetaxel-in-advanced-prostate-cancer
Experimental treatment kills prostate tumor cells while reawakening antitumor immunity
https://news.cornell.edu/stories/2026/06/experimental-treatment-kills-prostate-tumor-cells-while-reawakening-antitumor
Early study results from Johnson & Johnson show promising antitumor activity with combination of pasritamig and docetaxel in advanced prostate cancer
https://www.jnj.com/media-center/press-releases/early-study-results-from-johnson-johnson-show-promising-antitumor-activity-with-combination-of-pasritamig-and-docetaxel-in-advanced-prostate-cancer
Roswell Park Study: Inhibiting Regulator Protein Can Make Aggressive Prostate Cancers More Vulnerable.

BCL2 inhibitors in combination with a lutamide
https://physicianresources.roswellpark.org/news/roswell-park-study-inhibiting-regulator-protein-can-make-aggressive-prostate-cancers-more-vulnerable
Tiny silica particles wiped out aggressive prostate cancer in mice
https://www.sciencedaily.com/releases/2026/07/260708022158.htm
Researchers Uncover a Promising New Way To Stop Prostate Cancer From Spreading
https://scitechdaily.com/researchers-uncover-a-promising-new-way-to-stop-prostate-cancer-from-spreading/
I attended a presentation yesterday of an extremely interesting treatment for prostate cancer that is in phase 2 trials. It involves using a probe they put directly into a metastasis and it freezes the center, and then they put in a drug that spreads throughout the body and kills all metastasis. It’s been very successful in trials, they are using three different doses right now and trying to figure out which two should be part of the third phase of the trial.

you can find out more information about this trial and maybe even sign up for it at this website
https://legion100trial.com
The result: vitamin E supplementation increased prostate cancer risk by 17%.

New antibody drug stops aggressive prostate cancer from
spreading
https://www.sciencedaily.com/releases/2026/07/260718010151.htm
Optimizing Care for Patients With Metastatic Castration-Resistant Prostate Cancer
https://ascopubs.org/doi/10.1200/EDBK-26-516658
Scientists have developed a fully human antibody that halted the growth and spread of aggressive prostate cancer in preclinical research. Although more testing is needed, the drug’s unusual mechanism could open the door to a safer new treatment for advanced cancer.”
https://share.google/YPmWiFGdpeszVq511
CRISPR technology could augment treatment of immune cold cancers that don’t respond to immunotherapy. Can change prostate cancer cold metastasis so they can be treated.
https://www.urmc.rochester.edu/news/story/improving-immune-therapy-in-prostate-cancer

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Replies to "Well, this seems to be less than brand new technology. It also isn’t being used in..."

@jeffmarc

Jeff: thanks a million for sharing this extensive list of emerging prostate cancer detection and treatment approaches at various stages of development, clinical trials, and implementation.

Given my situation and my substantial pathological and biological risk of BCR, I am particularly interested in developments that could provide earlier molecular detection of recurrence, much more sensitive imaging at lower PSA levels, increasingly precise local treatments that minimize collateral damage to healthy tissues, and more selective systemic therapies.

I’ll review the materials in detail and will ask questions or add comments as I learn more. This is exactly the kind of information I was hoping we could share in this group so that we can all stay informed about what may be coming.