Seems as long as it is confined to the prostate and they can reach it, and it needs treatment, so called focal therapy (which can be up to 90%+ of prostate) are the BEST option. All that overgrading and super push to over-treat is out there, I am sure 3/4 of the pathology I had are plain wrong and were over graded. I am sure 3/4 of the recommendations for treatments I had were over-treatment. Seems the field is geared around that, and up to patient to catch it and only do what is needed. But to go after focal is not the place to start. Most places in the country may have teams that treat PCa but they have zero focal treatment available in hundreds of miles so they feel over-treatment is justified and never mention anything but overtreatment. The one doctor in my area who supposedly does focal treatments was only doing it in very rare cases and he routinely goes for over treatment recomendations because he makes more money that way. The place to start is not going after focal places, every day practices never mention anything but over-treatment prostatectomies or radiation with ADT, based on over-grading and making money. Plus pathology is real bad in my opinion, almost all out there is over-grading to cover in case of legal action, maybe these are better targets to go after.