@sallyo420 thanks for replying I have been off Mirtazipine three nights now and my anxiety is manageable but I can’t sleep past 3am due to histamine rush burning skin sensation so only getting four hours max for three nights feel very tired now and fear caving in. Cannot take any valerian or chamomile based support as on blood thinners. Prozac would not help me sleep either so feel a bit worried I will have to go back on Mirtazipine but that feels like failure- at what cost?