I have been on Keppra for about two years. Because I still have had a few mild seizures, my neurologist has upped the dose gradually. My major side effect is a worsening of my depression. I know that this is a possible side effect and if you are prone to depression, either take the lowest possible dose or try something else. My psychopharmacologist and neurologist tried me on Lamictal (sic?) but I had a major reaction to it and was hospitalized.

I will note that other than the above conditions, I am a reasonably healthy and fit 77 year-old and I don't know how much of my negative reaction is exacerbated by aging.