PMR is confounding, painful and so difficult to treat. I was diagnosed in October 2025 and have just tapered off prednisone. I have shoulder, hand and back hip pain, but not as severe. I also gained 15 pounds in a short period of time. My no. 1 complaint (besides the weight gain) is extreme fatigue and depression with uncontrollable crying. My next appt. is in October, so I’m trying to tolerate to see how my body is reacting by the time I go back. My rheumatologist has suggested infusions at a cost to me of $500/month! I choose to live with the pain, but the fatigue is seriously impacting my quality of life. Has anyone out there successfully treated the fatigue? If so, I would be forever grateful for any suggestions. Take care.