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Anyone have a hard time getting back to normal after ADT?
Prostate Cancer | Last Active: 5 hours ago | Replies (111)Comment receiving replies
Unfortunately, you didn’t clearly say that your testosterone was still near zero but it appears that that’s what you meant. You also don’t mention your age with she’s a major factor and testosterone coming back.
After being on it for six months, it took my brother over a year before his hot flashes completely stopped and his testosterone came close to 200..
Here is some information from PCa Commentary about testosterone returning
Examples of the relationship of the duration of ADT exposure to subsequent recovery to their
original T levels after stopping ADT are as follows:
- After 3 - 9 months of ADT nearly all men fully recover by about 10 months;
- After 18 - 24 months of ADT only 60% fully recover by about 3 years; and
- After 36 months of ADT exposure only 50% fully recover by ~ 5 years.
It is clear that after receiving ADT for longer than 6-9 months many men never fully return to their
T baseline. This raises the very important question of whether it is safe to offer replacement
testosterone in symptomatic men who have been rendered persistently hypogonadal (<230
ng/dL).
If your testosterone is not returning after a year, you could get testosterone replacement therapy through injections. It has been shown in recent trials that it does not cause the PSA to rise. That can get you back to feeling normal again. Something to discuss with your doctor.
Replies to "@lacraig1 Unfortunately, you didn’t clearly say that your testosterone was still near zero but it appears..."
@jeffmarc My first blood work six weeks post treatment (18 months Orgovyx) showed PSA still <.01 but testosterone has risen from <10 to 48. Regretfully, I don't have pre-treatment testosterone number. I still have plenty of hot flashes but am starting to feel a bit more "normal."
@jeffmarc Do men on Orgovyx versus Lupron recover faster in general? That is what I have heard.
@jeffmarc
You are full of helpful information, thank you.
My husband had a pathological left hip on July 14th 2026 after 10 months of diagnosis with Prostate Ca stage 4 with metastasis to the bones; 9 months of treatment with Erleada 240 mg and Lupron shots (x2 received since February). His hip repair was successful and his pain on left lower extremity has improved from severe (10) to (4-5). His PSA is 30 from a test 1 week ago. His initial PSA was 32 but it went up to 56 then down to 30.
My question is, are the current treatments of daily Erleada 240 mg and Lupron shots every 3 months adequate? These treatments are affecting his strenght, RBC/hemoglobin levels, weight, which we understand due to lower testosterone levels. He is 77.
I am concern about his psychological well being and I try to motivate him on a daily basis. I use cases that I read from this venue as examples of positive outcomes. Any resources that you know of that we can tap into?
@jeffmarc heb 17 maanden orgovyx gebruikt vanwege 12,5 psa en gleasonscore 9 ,graad 5 en na dat ik daarmee gestopt.werd voorgeschreven om dit 2 jaar te doen, bestraling 28 stuks beiendigd 16 julii 2025 en ook hormoontherape ben had ik na 2 maanden weer een orgasme , wel droog , logisch ook maar wel lekker, Ben ik nu een uiitzondering? de behandelings methode heb ik wel zelf uitgezocht, het is tenslotte wel mijn lichaam, waar ik zolang als ik nog nuchter van geest ben, zelf over beslis
@jeffmarc Well, Jeff... I guess I’m probably an exception then; I used Orgovyx for 17 months—my testosterone level was 7 at the end of that—and I had an orgasm again two months later. I’m 71 years old.
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@jeffmarc
My testosterone was even in my question.
it has creeped up to the mid-60s. I am 77.
I was on ADT for 3 months and am approaching this 10 month marker.
My concern is these symptoms plus lack of good sleep are affecting my heart and overall health.
I want to see an endocrinologist.