Billfarm here. I am following a protocol from an md anderson study on intermitent adt. Bcr up to 2.8. Orgovux/zytiga for 20 months. Fatigue overwhelming. Off drugs since march 2025. Psa hovering near undectacle since. Testosterone 63 . Psa tests monthly petscans each 6 months. Someone on here can cite the exact md anderson study showing imtermittent adt not inferior to constant adt outcomes. Be well!

@denis76 well they say number of lymph nodes and bone metasis do matter. However, I also believe how well you respond to treatment is very important. How quickly your PSA went down and what is the NADIR point. Did you have PSMA PET scan ? What did it sow? and what are the time frames. Of course it all matters to a degree but each person's cancer is unique and how quickly it is suppressed ( dropping PSA number) etc is very strong prognostic indicator. AS Jeff Marchi is fond of saying, in most cases of advanced PC today, it is more of a chronic disease than fatal. When it flares up, lots of tools nowdays to suppress it back into remission.

@denis76 well somewhat- it doctates what kind of treatment you recieve and for how long..Gleason score, metasis ( where and hom much) status and PSA. Then I would say your PSA after 6 mos and 1 yr are pertinent. AS I said, your response to therapy is a prognostic indicator of long term survival etc. Again everyone is different and landscape of PC world is littered with noteable long term survival of guys who started with many metasis and Gleason 9- 10.