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Anybody diagnosed with microscopic colitis?
Inflammatory Bowel Disease (IBD) | Last Active: 5 hours ago | Replies (501)Comment receiving replies
@szelisk Collagenous colitis is microscopic colitis. There are two types of microscopic colitis: Collagenous colitis and Lymphocytic colitis. They are both under the name of “microscopic colitis”.
Replies to "@szelisk Collagenous colitis is microscopic colitis. There are two types of microscopic colitis: Collagenous colitis and..."
@ndough, here is a basic summary of Collagenous Colitis (MC)
The strongest evidence is for collagenous colitis
A major genetic study examined 804 patients with histologically confirmed collagenous colitis and compared them with controls. It found three HLA alleles associated with increased risk:
HLA-B*08:01
HLA-DRB1*03:01
HLA-DQB1*02:01
These are all part of the HLA ancestral 8.1 haplotype. The study also found a protective HLA allele, HLA-DRB1*04:01.
This matters because HLA genes help the immune system recognize and respond to substances in the body and gut.
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@ndough, yes, you are 100% correct. However, there is a big difference between them. Generally, Lymphocytic colitis heals after one treatment of budesonide and is not known to recur once treated. Now, Collagenous colitis is a different story. Approximately 50% of patients relapse after Budesonide treatment. Of those 50%, about 20% go on to need additional treatments and potentially develop other chronic GI issues.