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Interesting studies posted today on JAMA and JAMA Oncology

Prostate Cancer | Last Active: 1 day ago | Replies (6)
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Profile picture for northoftheborder @northoftheborder

And for anyone interested, the second link (the clinical trial) compared different types of radiation therapy for treating early-stage prostate cancer:

- SBRT had a slight advantage in reducing bowel-related side-effects after 2 years
- SBRT had no advantage in reducing urinary-related side-effects overall after 2 years, but did show a slight advantage in reducing incontinence specifically
- SBRT showed fewer declines in sexual quality of life after 1 year
- SBRT did not improve disease-free survival after 3 years (in fact, it was slightly better for IMRT)

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Replies to "And for anyone interested, the second link (the clinical trial) compared different types of radiation therapy..."
toolbelt | @toolbelt | 1 day ago

@northoftheborder

Thanks for the summaries. One thought as to disease-free survival. SBRT may well be moving toward a focal boost approach where the entire gland receives 36.25 GY (7.25x5) and the primary lesion receives a focal boost of up to 50Gy (typically 40-47.5Gy). Hypo-Flame and SPARC studies show an improved disease-free survival and a minimal increase in bowel and urinary side effects as compared to normal SBRT. I had the 36.25 with a boost to 40. I had a Barrigel spacer. My RO visualized my urethra on CT, MRI and PSMA-PET and used urethral shaping to keep the urethra from receiving "hot-spots". So far, 32 months later, bowel and urinary side effects have been and continue to be minimal.

Stay Strong Brother, We Got This

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