I have been on Tagrisso 80 mg for 8 months. I, too, had the diarrhea, skin rash and also leg swelling. It has been manageable, fortunately with the medications for treating those side effects. I was on 9 rounds of Cisplatin with Alimpta, then 3 of just Alimpta. I have one more round to go. Then, I will only be on the daily Tagrisso. I have NSCLC EGFR positive Stage 1V. The tumors have shrunk and we are taking some time in September to take a few little vacations. The oncologist said it was fine. I have had a decent amount of energy the last week or 2 since a few days after the last Alimpta infusion, so that was nice. I also take Biotin, about 3,000 mg daily. I did NOT lose my hair completely for which I am grateful, but I did lose some. Good luck to everyone who is battling this awful disease themselves or with a loved one.