@bythesee5 and thank you, colleenyoung, for bringing the comment to this discussion group. As one who has treated with a checkpoint inhibitor immunotherapy for metastatic melanoma, you are correct that I've also encountered adverse effects although mine resulted in colitis and loss of weight which - as a sigmoidoscopy confirmed yesterday - has been temporary in nature due to the treatment I've received for that with the assistance of a GI specialist - but it's taken over 8 months to achieve that stability. Adrenal insufficiency is generally more complex to manage.

@bythesee5: how long have you been having these symptoms and do you remain on immunotherapy? Have you been working with both your oncologist and an endocrinologist to determine the most appropriate dosing of the hydrocortisone especially in conjunction wit h the Wegovy?