@bythesee5 and thank you, colleenyoung, for bringing the comment to this discussion group. As one who has treated with a checkpoint inhibitor immunotherapy for metastatic melanoma, you are correct that I've also encountered adverse effects although mine resulted in colitis and loss of weight which - as a sigmoidoscopy confirmed yesterday - has been temporary in nature due to the treatment I've received for that with the assistance of a GI specialist - but it's taken over 8 months to achieve that stability. Adrenal insufficiency is generally more complex to manage.

@bythesee5: how long have you been having these symptoms and do you remain on immunotherapy? Have you been working with both your oncologist and an endocrinologist to determine the most appropriate dosing of the hydrocortisone especially in conjunction wit h the Wegovy?

@colleenyoung I've only been on oral Wegovy lowest dosage for a week. So far no weight loss and a little nausea for a couple hours near mid day. I'm planning to keep on it for 30 days to see if there are any weight loss results. My oncologist encouraged me to try it but didn't have high hopes for the weight loss. At best, he thought I might lose 3 or 4 pounds. Has anyone else tried ways to lose the weight caused by permanent steroid use? Also anyone using hydrocortisone daily for permanent AI do you ever get energy from it? I hear this from doctors like we're supposed to feel good, pretty normal, and I never feel that way. I've heard others say that getting the dosing right is like tightrope walking and maybe I need to be taking more? But that makes me worry about more weight gain and type ll diabetes.