I can briefly share what is tracking for me and what I've been told. I've been diagnosed with Sjogren's, polyarthritis and Undifferentiated Connective Tissue disease. I was started on hydroxychloroquine last year. Prior to beginning medicine I started losing weight. Because I was trying to eat healthier with less inflammation I at first attributed it to that. I was slightly underweight to begin with so this was unintentional. As the past year has gone on the weight loss has become dramatic and last January my primary care doctor referred me to a gastroenterologist and also ordered his own tests. I had an endoscopy (which showed mild gastritis) which was consistent with autoimmune disease. There was no real follow-up for a few months but the weight loss continued. I had a barium swallow which came back normal and finally a liquid gastric emptying test which revealed delayed emptying almost three times the normal length of time. This was also followed by a colonoscopy that was normal with the exception of a small polyp. Since then my rheumatologist who is really sharp did small nerve fiber biopsies on my leg which showed SNF damage. I've had edema in my lower legs and other nerve symptoms. I also have had other autonomic dysfunction symptoms for a long time. According to my rheumatologist and information that I've read, this is an area that is particularly impacted but certain autoimmune diseases like Sjogren's. I am currently being treated for the gastroparesis and other SNF related complications. My rheumatologist is trying to go after the neurological source of these by starting me on mycophenolate; the goal is to have me approved for IVIG but I have to start with this med before insurance will agree. The doctor said it's very difficult to find a medication to slow down the attack on the nervous system that doesn't have side effects, but believes that until we do, food replacement is only a stopgap. I am 5'6" and have gone from 127lbs to 96lbs in 11 months. I realize that being diabetic is a different metabolic problem, but wondered what medications are being used to directly slow down the damage being done to your nerves? Has anyone discussed an IVIG medication track?