@cynl I was diagnosed with RA and osteoarthritis and it affects my hands and lower back the most. I started Plaquenil 5 mths ago and feel nothing from it. Had a bit of a struggle first taking it as it caused severe nausea and diarrhea but my body adapted mostly, still have a bit of that but I deal with it. When I tell my rheumatologist it still bothers me she says well then you can never take methotrexate, you wouldn't be able to deal with those side effects...so negative right? I thought the idea of these drugs was to keep the disease from progressing and hopefully give some relief. To tell your patient you can never take something puts such a spin on even trying it in my mind. Not sure what my next move can be....its so disheartening. wondering your experience with Methotrexate. thanks...