@chippydoo Orgovyx is my plan, assuming I can convince the urologist. I agree quality of life is an important issue. My argument is going to be just what you said - the half life takes me to 80 YO and the radiation oncologist said you likely won't get over all of the side effects at that age but which ones no one knows. My brother's neighbor is a year younger than me but better PSA and Gleason scores - he just quit Lupron after 6 months even though the recommendation was 12 months. Couldn't take it.