4 lower back surgeries. Both hips replaced. Left shoulde so destroyed i need Reverse Shoulder Surgery. Carpal Tunnel surgeries both hands. And Lung cancer with Lobectomy. Thru all of it my Sub Clinic would be in contact with Surgeons to decide how much opiates to give me post op o boy thru the ceiling doses. There is cut-off time between bupinorin and naltrexone a window where opiates will work. Boy they found that window on me AND Out I flew back when every doctor was handed out oxygen like M&Ms I was getting waaay more than needed for pain , 30s and 80s Yep and after each surgeries doctor says time to ween of and suffer No No No. First 6 years liquid hand cuffs then when Subs hit I was scared to death of getting super sick going from Methadone to Subs but had to be done with so many more surgeries up and coming SO bit down on peice of leather and switch to all Subs. Its a pain killer, antidepressant, and no need for opiates. Yep the Majic Bullet Good Luck