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Gleason7(3+4) - treatment options recommendation
Prostate Cancer | Last Active: 3 hours ago | Replies (317)Comment receiving replies
@jeffmarc
There are many recent studies that show that low testosterone can be a problem. I could not get the web sites to copy properly so you might have to Google the titles to see the articles. Following are a few:
"Testosterone Supplementation After Prostate Cancer Treatment
YouTube - ISSM International Society for Sexual Medicine" - Dr. Mohit Khera (Baylor College of Medicine) and Dr. Gerald Brock (Western U. London) explain the evolving view on testosterone and prostate cancer, noting a shift from seeing testosterone as harmful to recognizing potential therapeutic or preventive roles. Low testosterone is linked to higher risk of high-grade cancer, recurrence, and poorer erectile recovery. 3/28/25
"Testosterone replacement therapy following definitive treatment for prostate cancer: a scoping review of safety and efficacy | International Journal of Impotence Research"
Conclusion: TRT does not increase the advancement of prostate cancer and may actually decrease cancer growth. 11/26/25 summary of 12 studies.
"Testosterone and prostate cancer: What's the connection? - Mayo Clinic"
Conclusion: Studies have shown that testosterone replacement therapy doesn't seem to increase the risk of prostate cancer returning. 10/29/25
"Study Solves Testosterone’s Paradoxical Effects in Prostate Cancer" | Duke Health
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@pesquallie
I took a look at the links you provided. TRT does seem to be pretty well handled in a lot of cases. I don’t think this really got into the subject of not using ADT, Especially for new cases.
I do see that There are unknown exceptions to these Positive results..
“However, the findings from the 12 included studies suggest that, in appropriately selected individuals, TRT may be both effective and oncologically safe.”
They did say they underrepresented high risk individuals, so they were a little cautious in how they presented it.
“TRT may be cautiously considered in men with documented hypogonadism and stable post-treatment disease, provided that treatment decisions are individualised and closely monitored.”
These type of statements are the reason that I am not sure it really fits everybody. Those with serious cases have to be very careful.
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@pesquallie
I don’t understand why you didn’t include links to articles. Yes, testosterone is useful in higher grade prostate cancer, But for initial treatment ADT can work to reduce Metastasis and stop spread for almost everybody. It’s mainly the people that are resistant to hormone therapy that can get a benefit from higher testosterone.
I would like to see you post a link to something that Has a different point of view.