I take first thing in the morning when I first get up. If you take supplements put a 1 1/2 to 2 hours later. The only side effects I’ve had has been similar to pimples, like I’m going through puberty for the second time. I take the full dose of 80 mgs. Monitor changes if you have any and let your oncologist know. I’ve been on it now for over 2 1/2 years and I’m grateful I didn’t need chemo.