@ipg I was searching and reading clinical research data on transdermal estradiol and learned that transdermal estradiol acts as an anti-resorptive agent that locks in the bone-building gains achieved during a course of Forteo (teriparatide). Because stopping Forteo without follow-up therapy often leads to rapid bone loss, transitioning to a transdermal estrogen patch suppresses bone breakdown, stabilizes newly formed bone mineral density, and reduces the risk of future fractures.
Benefits of the Transdermal Route:
Liver Bypass: Delivering estrogen through the skin avoids first-pass liver metabolism.Lower Risk Profile: Transdermal application minimizes the risks of blood clots and strokes often linked to oral estrogen forms.
Consistent Delivery: Patches provide steady hormone levels in the bloodstream, helping keep bone turnover markers stable.

I am on an estradiol patch 0.025 mg twice weekly.