@njx58 @lori62yb

Osteoporosis drugs targets bone tissue receptors directly - it does not matter whether you weight 100 or 300 lbs

As far as how they leave your system - they circulate through your bloodstream and are filtered out by your kidneys or broken down by natural biological processes at a steady rate, regardless of how much you weigh.

In there words: unlike medications that need to soak through all your body fat or muscle to work (where weight matters a lot), bone drugs go straight to your skeleton or filter out through your kidneys at a standard rate, which is why your scale weight doesn't dictate the prescription size.

References

Drake, M. T., Clarke, B. L., & Khosla, S. (2008). Bisphosphonates: Mechanism of action and role in clinical practice. Mayo Clinic Proceedings, 83(9), 1032–1045. https://doi.org/10.4065/83.9.1032

Paik, J., & Scott, L. J. (2020). Romosozumab: A review in postmenopausal osteoporosis. Drugs & Aging, 37(11), 845–855. https://doi.org/10.1007/s40266-020-00793-8