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Gleason7(3+4) - treatment options recommendation

Prostate Cancer | Last Active: 56 minutes ago | Replies (302)

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@johnnyz
While 7 of 15 cores is good to know it’s even more important to know what the Gleason Scores were on those seven cores. Were they all 3+3? Were some of them 3+4 or 4+3. Or any of them 4+4 or 4+5.

Any of those group of scores could mean you need different treatment. Was the cribriform Large or small? My brother had small cribriform And just had five sessions of SBRT radiation and he’s doing fine three years later. If it’s large cribriform But you only had one 3+4 and it was only 10% of four then you could actually hold off and do active surveillance. I know a guy who’s gone well over a year with large cribriform But only a 3+4 and many doctors have told them there’s no urgency and he’s just stayed on active surveillance.

If it’s a 4+5 or 4+4 then you want to get a PSMA PET scan to see if there’s any spread outside the prostate. In that case, surgery is not an option usually you want to do radiation.

How high was your PSA at diagnosis? The higher it is the more urgent treatment is.

I need a lot more information to really Assist you.

Are you a patient that could have focal therapy? A lot of that is based on how much it is spread and how aggressive it is.

Were any of these things found in the biopsy intraductal, ductal, large cribriform, Seminal vesicle invasion, EPE or ECE. (Extraprostatic extensions extra capsular extensions). They can make the cancer much more aggressive.

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Replies to "@johnnyz While 7 of 15 cores is good to know it’s even more important to know..."

@jeffmarc Hi Jeff, my PSA is/was 10.8 at biopsy, Cribriform architecture is evident but <10%, and pattern 4 <5%. No IDC, bilateral cancer on both sides. Stage 2 unfavourable, but surgeon biopsy review suggested stage 1...No evidence of seminal invasion, EPE or ECE. Surgeon said NO to SBRT. Surgeon also leaned to pushing for Robotics RP

@jeffmarc Cores were one of 3+3, 6 more at 3+4 but pattern 4 only <5%