← Return to Post Prostatectomy 6 years. PSA <.01 until now. Anyone else ?

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I fully concur with Jeff.

With only one elevated PSA result, there is no certainty to this being an actual rise (vs “lab variation”), even though it naturally induces alarm/concern.

I completed salvage radiation for a local recurrence last November. My prostectomy was in 2015 and I went ten years with undetectable PSA (<0.1) until June 2025 when it rose to 0.11.

Just before starting radiation therapy, I switched to the Labcorp ultra sensitve PSA test. Going into radiation my PSA was 0.097. At three months after radiation (Feb 2026) it was 0.086. Then in May 2026, it bounced up to 0.113 (and yes, I was concerned). Since then I have done two more tests, which yielded 0.100, then 0.090. So, now I am trending down after an abrupt rise of 0.27. Was the rise real or just lab a variation? Hard to say at this point. Only time and continued testing will tell. My urologist, who is an advanced prostate cancer specialist said that the post RT PSA results indicate that my PSA is “low and stable”. I’m good with that.

If the 0.02 result is weighing heavy on your mind, there is no harm in repeating the test now to see if it is a lab fluke. Otherwise, I would advocate with my doc(s) to test monthly until a clear trend (up, down, or stable) emerges. Some docs might brush off the new test result, others may say let’s retest and level up the frequency. If you have the brush off type of doc (I have, in the past), advocate firmly for what you want to happen next. I once even went to my PCP to get a test order when my then urologist was uncooperative.

However you proceed, I feel your anxiety. Both good news and bad news that you are in a state of uncertainty at the moment.

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Replies to "I fully concur with Jeff. With only one elevated PSA result, there is no certainty to..."

@melvinw
My concern has always been the level of 'high risk' that was diagnosed post surgery. Prior to surgery, my PSA was elevated (6) but stable for 3 years, so it was a 'wait and see'. Then it began to rise quickly with a doubling time of about 3 months. That is when the decision was made to act. I am hoping this is not a repeat of that scenario (i.e stability then surge). Your PSA of .09 seems low to have begun radiation. My impression was they do not consider a true BCR until .2 is reached? There seem to be so many opinion variations on this. I am a University of CA patient and they had said initially "if it goes up, we begin Lupron". That was 5 or so years ago so I am thinking they have adjusted thinking since then.