The patient studies show generally “most” people improve over a few weeks as your system acclimates to the effects of Tymlos on your parathyroid. Most of the initial effects are within an hour as the Tymlos leaves your system rapidly within 5 hours. I had the headache, nausea, rush feeling mostly for the first few weeks. For me it took a little longer but most of the side effects are much less now (9 months) and what remains doesn’t last long. Never into the next day. Take note that some people can get what is called an “anticipatory effect” where you psychologically expect the reaction. Try changing to another room where you do your injections…it helped me to do that and change the time slightly by a half hour or so.