I have been off prednisone for PMR for 6 months. I am still on 3mg LDN taken at night. Went up to higher dose a couple times and sleep was disturbed. I am not positive it helped reduce steroids, but did seem to keep mood positive. When I recently quit LDN for two days I did not feel very good, so I stay on 3mg LDN. I know this is not a scientifically accurate test. I feel like it helps with some sleep, a little pain and mood.