@debafitz I just received my second Reclast infusion, and so far so good. I did very well last year after the first and attribute that to this website and the suggestions made here, as well as the info from my endocrinologist. I began hydrating well a few days before the infusion, day of, and a couple days after. I also started 650 mg of Tylenol after each meal a couple days before, day of, and the day after. In addition I took a Claritin the day before, day of, and day after. All of these help to minimize the chance of an acute phase reaction. The only "strange" thing I had happen within this past year is acute lower back and thigh pain out of the blue in May...10 months after the first infusion. It required steroids, muscle relaxants, and pain meds for 5 days. We still aren't sure if that was possibly a delayed reaction to the infusion. I may have over done it working with weights but honestly can't remember. It will be interesting to see if I experience anything like that again. I cannot take Forteo or Tymlos, and the endo won't suggest Prolia because my sister had a terrible reaction to it. So Reclast is it for me unless some new promising drug surfaces.