@lurawilson Thank you for your kind reply:) My p1NP went from 74 to 119 and CTX from 946 to 665 for three months on Tymlos. I get a DEXA in two months. I would like HRT if it helps bone, but trying to see if hyperthyroidism or high LDL levels would be affected. I was on bioidentical topical (thigh) cream with estrogen/progesterone combo and felt wonderful. They made me stop after ten years, but now they seem to be allowing it again. However, I stopped taking them about ten years ago and now they saw I can't start again because it has been too long. My doctors don't seem to want to give me HRT but I am still researching. What HRT form do you use? Pros/cons? Any advice on convincing my doctors?