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P1NP number on Tymlos

Osteoporosis & Bone Health | Last Active: 2 days ago | Replies (64)

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Profile picture for lurawilson @lurawilson

@summera1 yes I got good news for my lumbar spine and thanks for reminding me to post an update. My lumbar spine went down to -2.2 which is even lower than what it was in 2022. However they did see a compression fracture at T8. Here are my scores
2022
Lumbar spine -2.8
R hip -2.5
L hip -2.9
2024
Lumbar spine -3.3
R hip -2.6
L hip -2.6
2026
Lumbar spine -2.2
R femoral neck hip -2.5
L femoral neck hip -2.7
Forearm -1.8
Total R hip -2.1
Total L hip -1.8
This is the first time I got total hip readings and femoral neck. My bone markers also improve. I have been on Tymlos and HRT for 1 year . I plan to stay on the Tymlos for another 6-12 months depending on my bone markers and then I will get a reclast infusion and take a drug holiday but stay on HRT indefinitely. Hope that helps!

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Replies to "@summera1 yes I got good news for my lumbar spine and thanks for reminding me to..."

@lurawilson Thank you for your kind reply:) My p1NP went from 74 to 119 and CTX from 946 to 665 for three months on Tymlos. I get a DEXA in two months. I would like HRT if it helps bone, but trying to see if hyperthyroidism or high LDL levels would be affected. I was on bioidentical topical (thigh) cream with estrogen/progesterone combo and felt wonderful. They made me stop after ten years, but now they seem to be allowing it again. However, I stopped taking them about ten years ago and now they saw I can't start again because it has been too long. My doctors don't seem to want to give me HRT but I am still researching. What HRT form do you use? Pros/cons? Any advice on convincing my doctors?

@lurawilson, your results are wonderful, especially thr great improvements in your hips. Congratulations!

I read your previous posts - are you still on the same HRT dosing with no change? If you are comfortable sharing, what are your latest BTM readings? I'm very curious about estrogen's effect on the markers when used alongside an anabolic like Tymlos or Forteo. Thank you!