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Side effects of ADT + RT

Prostate Cancer | Last Active: 4 hours ago | Replies (9)

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I had 40 sessions pelvic IMRT 80gy over a year ago along with Orgovyx and Zytiga / Prednisone which I'm still taking for about another six months. I didn't experience any burning sensation, however urinary frequency and urgency began about halfway through the radiation treatments. This continued for several months afterwards and caused me considerable stress especially the urgency when I was away from home. It has mostly abated at this point in time. I still get up twice a night to pee sometimes only once if I don't drink anything a few hours before retiring. Anyhow, my bet is with more time your situation should improve. I'm guessing, but you're burning sensation is likely due to radiation rather than ADT or ARPI. Dysuria can happen but I think rarely from the drugs? What type and how many radiation treatments did you have. I believe the shorter courses are more likely to involve radiation cystitis.

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Replies to "I had 40 sessions pelvic IMRT 80gy over a year ago along with Orgovyx and Zytiga..."

@swl1956
50.4 gy (28 sessions) to pelvic LNs and 70gy (28 sessions) to prostrate, SV & nodes. That's in the Radiation treatment summary.
Till date, there were absolutely no issues either on burning or frequency.

Thanks for your detailed response. Hopefully this should subside soon.

@swl1956
You don’t have to get up twice a night to pee if you get the right drug combination.

I am on Myrbetriq And it works great to stop that urgency at night, I don’t have it at all anymore. I used to wake up multiple times at night feeling I needed to go knowing I didn’t.

There’s another drug called Gemtesa Which works pretty much the same.

Ask your doctor if you can get one or the other and you can stop getting up in the middle of the night. You don’t have to take them forever, but they do help a lot.