I've often wondered what percentage of people have the serious or seriously annoying side effects. It feels like there must be many as not many on Mayo Connect report good success with minimal side effects.
I finished my last (all 12) Evenity 5 weeks ago. In general, I had minimal side effects, some bone and muscle pain - but manageable with minimal motrin and mostly during the earlier months. It would pop up now and then the last 6. And in the first 4-6 months, I would get acid indigestion ...would start on day 10, randomly occur for 10 days, and stop until the next injection. Go figure! At the injection site, arms, I would get slight swelling for about 24 hours. Mostly the effects were just annoying and sometimes fatiguing but the results were excellent.
Spine was -3.0, now -2.0, considered a 14.4% growth
Hip was -2.1, now -1.9, a 5% improvement
Did not have comparable markers at the start, but now my P1NP is 36 and CTX is 208. I believe this shows a stable condition.
I'm now in low bone and out of osteoporosis. While my Dr and I had many discussions re follow up with Reclast and Prolia, I started Prolia yesterday. Was not wild about either but acknowledged that I needed to take one or the other.
I'm 77 yrs, and had never taken any osteoporosis drugs (to the Dr dismay) even though I'd been in osteoporosis for over 10 years. In this case waiting for improved drugs was probably prudent! I've never broken bones, I'm active and in good health. The decisions we have to make are tough but important.