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Looking for advice on next steps. 71yo in excellent health otherwise.

MRI in Jan 25 showed probable lesion and possible metastasis. Biopsy in Feb 25. Gleason 8. PMSA Pet Scan in March showed spread to one lymph node, pelvic bone metastasis, and possible rib metastasis (but very low score). Started 2 years of Orgovyx and Xtandi. Consistent with the STAMPEDE trial for low volume metastasis had 20 sessions radiation for the prostate and the node in May 2025. Sept 25 PMSA showed remission with much lower SUV values in both radiated areas and bone. PSA is undetectable and testosterone is in single digits. So far so good.

Jan. 26 some blood in stool. Diagnosed as radiation proctitis in May 2026 by colorectal surgeon. Did 6 weeks of Sucralfate enemas and bleeding is much less - once every few days and a small amount. What to do next?

Surgeon suggests either active monitoring, formalin, another round of Sucralfate, or hyperbaric. Says it is my call. What would you do in my case? To be honest it doesn't bother me that much. Thanks in advance.

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Replies to "Looking for advice on next steps. 71yo in excellent health otherwise. MRI in Jan 25 showed..."

@roxy2017
Just finished 30 HBOT sessions on July 9 for radiation cystitis and enteritis. It's beginning to help. Should take 3 to 4 months for significant healing . I'm overjoyed with the results.

@roxy2017, I would have the hyperbaric treatment. It reduces inflammation in your entire body, even helps your bones. Losing a little blood now and then isn't so troublesome, but you can become anemic from that constant loss. Bleeding with proctitis (actually proctopathy) is cyclic. Any way with radiation you are already at risk of anemia and with ADT you are at risk of bone loss. (If you haven't had a dexa, you should).
Hyperbaric treatment is a time investment, but it is worthwhile.