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Thanks for the input, Phil.
However, while very high PSA doesn't always mean cancer, IF diagnosed with cancer, then any cancer with initial PSA >20 is defined as high risk...... per NCCN guidelines. Two oncologists at Mayo walked me through this when I questioned the rating.
Respectfully, I can't imagine Mayo doctors using "unscientific" data.

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Replies to "Thanks for the input, Phil. However, while very high PSA doesn't always mean cancer, IF diagnosed..."

@datasource No, you’re right about that as far as the guidelines are concerned.
But there are those very low PSA cases which turn out to be extremely aggressive, right? And cases where cancer is found along with BPH, also a driver of PSA.
I don’t know (and I have not checked recently) if the guidelines have been updated to take this into account…ie, have they added the Decipher score and others to the diagnostic criteria?
There must be tons of men out there with lower grade cancers, BPH and high PSA’s - some even on AS. Best,
Phil