@tbgb50
When I became castrate resistant to ADT, my oncologist, added Casodex to my drugs. It kept my PSA at the same .2 for three months and then it started rising steadily, By 12 months, it hit 1 and continued to rise, didn’t work very well. I then went on Zytiga but even it did not stop my PSA from rising until 9 months later when it finally hit 2.2 and started dropping. A year and a half later I went on Darolutamide And my PSA has been undetectable for the last 33 months.

So in my case, low testosterone was not enough, I was resistant to that. I needed a blocker like a lutamide, But a first generation lutamide Like Casodex (Biclutamide) was not adequate.

I do know a guy who spent five years going on and off Casodex, Every time his PSA would start rising, he would go on it, When it dropped to undetectable, he would go off and then wait until it went back up again. Not what you call a successful long-term strategy. He moved on to a lutamide When Casodex would no longer work.