Taking trazodone and Ativan (lorazepam) together can cause dangerous side effects like extreme sleepiness, dizziness, confusion, and slowed breathing. Both drugs slow down your central nervous system. You should only take them together if a doctor tells you to do so.

Trazodone and Benadryl together is generally not recommended because both drugs cause drowsiness. Combining them can lead to extreme sleepiness, dizziness, confusion, and a higher risk of falls or accidents.

Combining trazodone and Unisom is generally not recommended because both cause severe drowsiness, dizziness, and confusion. Taking them together multiplies their sedative effects on your brain, which can lead to extreme morning grogginess, poor balance, and dangerous falls.

What I found. I would not take together without consulting your doctor or possibly a pharmacist.u