annaolivia, the question for the two recommending anabolics-- Tymlos or Evenity would be: After a year on Prolia that was ineffective would I be subject to the devastating rebound that Prolia causes.
While it doesn't make a lot of sense to continue on an antiresorptive when they haven't been effective, the risk of Prolia rebound might be a more significant concern.
You probably know that Prolia effectively represses the release of the cells that resorb bone, but Prolia doesn't prevent their development. They increase in number and size and wait for you to stop taking the medication.
Stopping without using an antiresorptive like Reclast or Fosamax can cause multiple fractures often in the spine, in the first year after stopping.
Evenity slows the production of new osteoclast- the cells that break down bone, but doesn't stop the cells that Prolia has already proliferated.
Is anyone ordering bone markers for you. They would be helpful if you decided to take a less potent than Reclast antiresorptive like Fosamax in the interest of switching to Tymlos or Evenity a little sooner than the two years that Reclast is usually effective.
I would contact each of these doctors recommending Evenity and Tymlos with this important question of rebound either by chart or by phoning and getting an answer through their nurses.
My understanding is that even with only one year of Prolia you risk rebound. But I'm not a medical person.
You might ask for bone markers so you don't lose any more time taking drugs that aren't effective for you.
@gently the crazy thing is MD Anderson wants me to go from Prolia to Evenity directly, my local NP in South Carolina, who works on bone Health said Tymlos will work better without alendronate in my body, but a major osteoporosis clinic is like no, you have to do Reclast or Fosamax at the very least. We need a study on rebound versus anabolic concerns.🙏🏼