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I believe there are varying opinions on this. I had 20 sessions of IMRT (photon). 8 months later, PSMA PET scan showed increased uptake in a portion of my prostate. I asked my RO if it could be radiated again. A flat "no" was the answer. "You received a lifetime dose"

RO left the practice and I asked my new RO the same question. "While we don't like to, in some cases it can be done, however, I wouldn't even consider it until 3 years after the initial treatment since side effects can take that long to appear." So, the answer I got was a definitive maybe. This was with photon though. Don't know if proton makes a difference.

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Replies to "I believe there are varying opinions on this. I had 20 sessions of IMRT (photon). 8..."

@mjp0512 Dr. Rossi has a lot of information about proton (& photon) radiation in his portion of this 2023 Mid-Year PCRI conference: https://www.youtube.com/live/WTqPnSRYtW4

He touches on re-radiation at about timestamp 4:53:00.