Hi Barbs,I've been on Tagrisso for 8 months now. I get mostly dry nails and chipping or breaking skin on my fingers. In the morning when I brush my hair, I get more hair falling. Perhaps it's dry hair. Drinking more fluids makes a. difference. My system gets regular (somewhat on softer side). every morning. sometimes twice a day. Really this is all I experience. I'm very grateful and lucky I'm doing fairly well on it. I'm sorry for those having more series effects that affecting daily quality of life. Wish you all the best. Hugs and prayers.