@catheem - Bupronorphine is synthetic morphine and usually takes a few weeks to initiate pain relief to the patient. I have been taking in slowly increasing dosages for arthritis in my spine that has recently been compounded by osteoporosis and the discovery of fractured vertebrae at L3/L4 (old fractures that have become deformed) also at T 12 and L1. I also have two replacement hips, the first in 2016 and the second in 2019…..and recently underwent open heart bypass surgery that while being perfectly successful - it seems that my lungs have been arguing with it ever since😂😂.