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Osteoporosis & Bone Health | Last Active: Jul 29 7:17pm | Replies (155)
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I started Tymlos injections in May 2026 and the leg pain seems constant and is concerning to me. Each morning feels like I've run a marathon in my sleep. Soreness and sometimes a sharp shooting pain in my thighs. It's only been 2 months! It makes exercising even more difficult. Doctor advises the pain should subside after my body has "acclimated" to the medication but I am skeptical. Can anyone who's been doing injections for 6+ months offer any wisdom, hints or tips? Thank you in advance.
Replies to "I started Tymlos injections in May 2026 and the leg pain seems constant and is concerning..."
@rebeccas3
9 months in on Tymlos…just started getting leg pains mostly at night
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@rebeccas3 Have you considered lowering your dose (number of clicks on your injection) to give your body a break from the pain? I experienced the same thing, especially when I had switched to nightly injections. (I quickly switched back to morning injections, hydrated well, etc). I lowered my dose to 40 mcg (4 clicks), with the hopes of titrating back up slowly. However, now that I am into my fifth pen, I have not been able to do so due to side effects. I figured the benefits of a lower dose will outweigh having to stop the medication. I have my next DEXA bone scan at the end of August . Hoping for the best. My bone markers still show that I am in an anabolic stage with a good P1NP to CTX ratio. Good luck!!