@barb73 - welcome to Mayo Clinic Connect. I had similar symptoms when I was on semaglutide/Wegovy previously in 2024. Coffee was at times a trigger. I also was doing what my family called "death burps."

I did have to talk to my doctor and a gastrointestinal doctor I happened to be seeing at the time, and I was prescribed some medications that helped with stomach cramping and nausea, which I was really struggling with.

I think most doctors prefer you start with medications for these symptoms which are OTC and more benign, which you are doing. If no luck, I'd encourage you to tell your doctor about what's going on and what you've tried so far, and ask what else might be available.

I did not love, nor did my primary care doctor love, prescribing me one medication to deal with the effects from another. But it was worth it to me at the time, so I did it.

After losing insurance coverage for over a year, due to maximums in my plan at the time, I did regain most of the weight I'd lost. So, I'm now on Wegovy again. This time, I'm only moved up to the next dose when my side effects are under good control. I've been at most doses for 3 months. This is crazy-making slow for weight loss, but it's been a much smoother process side effect-wise.

Did the simethicone (Gas X) help you?

@barb73 I think your doctor is increasing your dose too fast. I noticed an increase in side effects when I went from 5 mg to 7.5 mg so asked my doctor if I could just stay at 7.5 mg for a few months since I was losing weight and tolerating the side effects at that dose. Why risk having worse side effects if I’m making progress on the current dose. That’s working well for me and I plan to stay at 7.5 for as long as it’s working. You don’t have to keep increasing the dose—talk with your clinician about staying at a lower dose for a longer period of time.