I believe I have been living with PN in my hands since I was about 19 years old. It may have started as a result of a traumatic experience at that time? It may have been because my kidneys were failing without my knowledge and which only came to light when I was diagnosed with end stage renal failure at age 51. My doctor said that the xray of my totally shrunken kidneys suggested that my kidneys had been failing since childhood! I had a kidney transplant 20 years ago which has been very successful but the PN still affects my right hand a lot of the time. I am presuming that it is PN. It has affected my whole life psychologically as It was dismissed as being "all in my head" when I originally went to my doctor in my early 20s. Reading some of the case histories here resonate very strongly with me . It has taken me a long time to investigate what my problem could be so thank you for the opportunity to tell part of my story.