I was on Actemra monthly infusions for 5 years. Had GCA (diagnosed positive via biopsies on both sides) and after 5 years of infusions blood work finally returned within normal limits. Went off infusions with no side effects. Recently was on Methotrexate as a caution post stroke. Side effects of Methotrexate were hair thinning and possibly loss of appetite. I am off both Actemera and Methotrexate for a year or so and feeling great. No cure for GCA therefore in remission and keeping my fingers crossed that it remains the same.