Has your team offered any help ? There are many meds to manage nausea—I hope you find the one that works for you…i had mostly Opdivo, and one infusion of Yervoy added in…the combo is a kicker ! What other symptoms do you have—some might need immediate attention, like belly swelling and pain and tiny stools—in my case a fast developing blockage, caught in time….wishing you the best, to feel better soon…these meds really kick cancer…

Thanks for good response nycmusic. To summarize, no symptoms first week after O+Y. Then moderate to severe fatigue and nausea for the next week, including soaking bed sweats and shaking chills/rigors.
Symptoms noticably improved morning of day 12. Mild nausea and fatigue, small changes maybe but made the difference between able to function and not. Now day 14, mild nausea and fatigue but able to function.

Knowing that symptoms will improve makes them more tolerable. Learning about mechanisms causing nausea and the many non-pharmacologic treatments, my PCP has been helpful with this. I plan to put together a preventive plan with help from PCP and suggest preventive measures to Mayo treatment team before next infusions.