@jopier Hi and welcome to Mayo Connect. I understand the gut punch of the diagnosis. When I got mine, I was just kind of numb to it all. In shock and disbelief. Like you, mine was/still is inoperable. It has spread to my liver. What makes yours inoperable? For me, a few rounds of chemo gut punched me harder to let me know that I was in for a fight for my life. What chemo/chemos are you taking? You are blessed to have a good support system. You are already feeling the mental and emotional anguish that accompany the physical trauma that go with a pancreatic cancer diagnosis and treatment. I think a second opinion can't hurt even if it only confirms your treatment plan. That alone can give you some peace of mind. Where are you currently being treated?