Well..some of the illness I don't know anything about.. but..I'm 72 and have been constipated all my life.. never really bothered me.. then.. an antibiotic blew a hemorrhage in my stomach and it was "all hell" from there.. for the past 6 1/2 years.. so I feel you..I have tried Amtiza Linzess and finally Trulance.. the Trulance worked and I only have to used Miralax once in a while..or some prune juice..(I have maybe..the rheumatologist isn't sure ..scoleroderma, systemic. a surprise diagnosis of fibromyalgia(WPI 19..who knew? ..compaired to the stomach stuff!!..Hurts!!) And am in 3rd stage kidney failure (no one told me for 3 years and have alot of kidney stones..) I also have panic attacks (caused p[rimarily by this being sick) and anxiety and can't sleep and really tired all the time..SO step one I think.. talk to your Gastro..I always start there..if it isn't working nothing else matters..(I've been to ER so many time and hospitalized at least 3 for constipation.. once had a blood pressure of 60 over 40 because I sweated out all my fluids trying to get something up.. or out any way possible!! I was diagnosed with pyloric stenosis which they booted 3- 4 time to stretch it (wasn't born with it.. probably due to the IDK scoleroderma) and a tortuous colon.. he said your bowels go up and down now sideways you've been constipated so many years.. you are so young to be suffering so much and there is a solution out there.. talk to a good rheumatologist..(I just got diagnosed with CSU Chronic Spontaneous Urticaria by an allergist.. I finally went and saw one).. you might try.. these tests to.. Celiac..and Alpha Gal. watch out for sucralose..it's a good gut bacteria killer..(I take 2 VSL3 Probiotics every AM).. try some elimations from your diet and keep notes...God healed my tortious colon 2 weeks before I was going to see a surgeon.. pyloric stenosis is healed to.. I am going to pray for you sweetheart!! You are far too young to be going thru all of this!! Lifting you up to the Lord right now!!