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← Return to GLP1 to combat weight gain and A1C increase while on ADT?
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GLP1 to combat weight gain and A1C increase while on ADT?
Prostate Cancer | Last Active: Jul 25 12:06pm | Replies (34)Comment receiving replies
Or you could cut down on carbs and sugar. A1C isn't magical, it's usually a result of our bad habits and sugar addiction. And yes, I know some are some that are genetically predisposed. But most aren't. I am in the pre category as a sugar junkie. It seems most don't want to do the harder work of dealing with their mental health issues that is driving medicating with drugs, alcohol and sugar. Easier to take a shot of pill and keep going with the habit.
Replies to "Or you could cut down on carbs and sugar. A1C isn't magical, it's usually a result..."
@chippydoo Sugar is not the problem. It is the reduced ability of muscle tissue to take up glucose. With normal digestive function 75g of glucose can easily be processed (glucose tolerance test). Most sugar is stored in muscles or the liver as glycogen. If the muscles do not take up the sugar the body converts it to fat. That futher reduces the ability to process sugar. Reducing sugar intake is a way to manage spikes in an impaired digestive system. Of the many T2 diabetes drugs only GLP-1s and Pioglitazone directly increase the ability to move glucose out of the blood and into muscle cells. It is easier to take a pill, but also more effective if they are the right ones.
@chippydoo This is a huge battle between the ears. I’ve been obese most of my life from childhood. In 2020 I was getting within sight of diabetes. My doctor told me that losing 20 lbs. would correct it, and with my wife’s help and an old Weight Watchers menu I instead lost 40. In a couple of years I had gained back 10 and was holding on until diagnosis, and I’ve gained 25 since, mostly around the belly. So I’m basically back where I started. I’m exercising vigorously regularly but my fork is betraying me. My wife doesn’t want me to start GLP-1, because it seems only temporary, but I have to take action somehow.
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@chippydoo This has zero to do with bad habits or sugar addiction. I have diabetes on both sides of the family, and I've been able to keep my A1C down to 5.8 and 5.9 over the last few years. Prostate cancer introduced a new factor into my equation - ADT. The driving factor of my most recent A1C increase is 100% ADT related.
ADT raises A1C by driving insulin resistance, increasing fasting glucose, and worsening overall glucose variability. The effect begins within the first 3 months, continues to rise at 6–12 months, and is strongest with long‑duration ADT (>6 months). I'm 9 months into an 18 month regiment.
I'm active, playing softball 2-3 times weekly for 2-3 hours at a time. I lift weights and do resistance band training. I have no sugar addiction; don't drink or do drugs. Diet? Yes, it could be better, but this increase is a direct result of ADT and why I was curious if others have used GLP-1s while going through ADT. It appears many have and with good results.
GLP-1 isn't a long-term solution - but may be a short-term tool to combat the impacts of ADT on the body.