@letsjustbreathe I would try to keep an open mind about the antibiotics. I was also 61 when diagnosed with aspergillosis and MAC. Since I was having symptoms of fungal infection they treated me with an antifungal first, Voriconazole. I did watch and wait a few months then started the big 3 for MAC, azithromyacin, ethambutol and rafampin. I started following a high calorie diet prior to antibiotics since I knew that weight loss was an issue for most. As mentioned on this post I included a Greek yogurt daily and a probiotic. Due to rafampin’s interaction with one of my other meds I stopped that and started Arikayce, an inhaled antibiotic. GI side effects improved after about 3 weeks of taking the antibiotics. I still get some occasional nausea that resolves in a couple hours. I had my first negative MAC culture recently. So, hoping another 12 months of meds. If your side effects are more severe your doctor can make adjustments to find a plan that works for you. Best of luck with your journey. We are all here to help support!